Biggest supporter of metformin:
Written April 2017, with 57 citations
Most promising data
15% higher survival rate using metformin over control over 5 years.
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls, 2014
However, Some disagree because it lacks good RCTs for HEALTHY NON-DIABETIC individuals. It also lacks clinical evidence for boosting of human longevity- Especially maximal lifespan.
At 14.12s, shows a 2012 meta of RCTS, showing poor Relative Risks(RR)
What is the mismatch?
1. Targeting Aging with Metformin (TAME),